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10th International Symposium on Bordetella

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[title size=”1″]About the meeting:[/title]
[one_third last=”no”][map address=”Trinity College Dublin, Ireland” type=”hybrid” width=”350px” height=”350px” zoom=”14″ scrollwheel=”yes” scale=”yes” zoom_pancontrol=”yes” popup=”yes”][/map][/one_third]
[two_third last=”yes”]This meeting was organised at Trinity College Dublin, in Ireland from September 8th to September 11th 2014.[/two_third]

[title size=”1″]Program of the meeting:[/title]

Sunday 8th September

  • 18.00 Kingston Mills, Trinity College Dublin, Ireland
    Welcome and opening remarks from Conference Organizer
  • 18.15 Darina O’Flanagan, Director, Health Protection Surveillance Centre, Ireland.
    Official opening of the meeting with comments on Pertussis in Ireland
  • 18.30 Erik Hewlett, University of Virginia, Va, USA
    Historical perceptive of the pertussis / Bordetella meetings
  • 18.45 James Cherry, UCLA, Ca, USA
    Review of the pertussis vaccine trials
  • 19.15 Welcome Reception

Monday 9th September

Session-1 Genomics and Evolution of Bordetellae (Chair: Jeff Miller)

  • 8.30-9.00 Simon Harris, Sanger Institute, Hinxton, Cambridge, UK
    Comparative genomics and evolution of Bordetella
  • 9.00-9.30 Andrew Preston, University of Bath, UK
    Filling in the gaps: genome sequencing of Hinzii, Holmesii, Trematum and Ansorpii
  • 9.30-10.00 Ruiting Lan, University of Sydney, Australia
    Evolution of Bordetella pertussis in Australia
  • 10.00-10.15 David Hot, Institute Pasteur of Lille and Univ. Lille, France
    Short talk: Characterisation of BprC an Antisense Small RNA of the 5’UTR of Bordetella pertussis Major Virulence Regulator Gene, bvgA
  • 10.15-10.45 Coffee
  • 10.45 -11.15 Frits Mooi, RIVM, The Netherlands
    Using “omics” to identify genes involved in adaptation and effective vaccine targets
  • 11.15-11.45 Eric Harvill, Penn State University, Pa, USA
    Emergence of multiple pathogens amongst the Bordetellae
  • 11.45-12.00 Daan de Gouw, University Medical Centre, Nijmegen, The Netherlands
    Short talk: In vivo Transcriptional Responses of epidemic and previously dominant Bordetella pertussis Strains
  • 12.00-12.15 Qing Chen, CBER/FDA, Bethesda, MD, USA
    Short talk: Bordetella pertussis RisA Activates bvg-Repressed Genes (vrgs) due to Mutation in risS
  • 12.15-13.30 Lunch and poster viewing

Session-2 Pathogenesis and Immunity (Chair: Alison Weiss)

  • 13.30-14.00 Peter Sebo, Institute of Microbiology of the ASCR, Prague, Czech Republic
    Adenylate cyclase toxin- role in pathogenesis and subversion of immunity
  • 14.00- 14.30 Francoise Jacob-Dubuisson, Institut Pasteur de Lille, France
    New insights into signal transduction by the sensor-kinase BvgS
  • 14.30-15.00 Peggy Cotter, University of North Carolina at Chapel Hill, USA
    Roles for three of the four acellular pertussis vaccine components revealed by studying B.bronchiseptica in its natural hosts
  • 15.00-15.30 Tea/Coffee
  • 15.30 –16.00 Nick Carbonetti, University of Maryland, Baltimore, USA
    Multiple mechanisms of pertussis pathogenesis mediated by pertussis toxin
  • 16.00-16.30 Rachel Fernandez, University of British Columbia, Vancouver, Canada
    Immune modulation by Bordetella surface structures
  • 16.30-16.45 Kaatje Smits, Université Libre de Bruxelles, Brussels, Belgium
    Short talk: Dissection of the Bordetella pertussis Memory T Cell Responses in 9 to 12 Years-Old Children Vaccinated with Whole Cell or Acellular Vaccines
  • 16.45-17.00 Cecile van Els, RIVM, The Netherlands
    Short talk: Distinct End-Differentiation Patterns of Human Pertussis-Specific CD4+ T Cells
  • 17.30-19.00 Poster session


Tuesday 10th September

Session-3 Epidemiology, Infant Mortality and Diagnostics(Chair: Qiushui He)

  • 8.30-9.00 Nicole Guiso, Institute Pasteur, Paris, France
    Human Bordetella species: what’s new
  • 9.00-9.30 Tom Clark, CDC, Atlanta, USA
    Pertussis epidemiology and vaccination in the United States
  • 9.30-10.00 Scott Halperin, Dalhousie University, Halifax, NS, Canada Epidemiology of pertussis in Canada: do we know what’s happening?
  • 10.00-10.15 Manisha Patel, Centers for Disease Control and Prevention, Atlanta, USA
    Short talk: Vaccine Effectiveness and Duration of Protection of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis among Adolescents, Washington State, 2012
  • 10.15-10.30 Natasha Crowcroft, Public Health Ontario and University of Toronto, Canada
    Short talk: Comparing the epidemiology of Pertussis in an Under-Immunized Community with the General Population during an outbreak in Ontario, Canada
  • 10.30-11.00 Tea / Coffee
  • 11.00-11.30 Peter McIntyre, National Centre for Immunisation Surveillance and Research, NSW, Australia
    Epidemiology of pertussis in Australia: Impact of vaccine strategies
  • 11.30-12.00 Alberto Tozzi, Bambino Gesù Children’s Hospital, Rome, Italy
    Epidemiology and diagnosis of pertussis in Italy
  • 12.00-12.15 David Litt, Public Health England, London, UK
    Short talk: An unexpected large rise in pertussis cases in the England and Wales during 2012 is not associated with genetic changes in the B. pertussis bacterial population
  • 12.15-12.30 Lucia Pawloski, Centers for Disease Control and Prevention, Atlanta, USA
    Short talk: Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US
  • 12.30-13.30 Lunch and Poster viewing
  • 13.30-14.00 Kathy Edwards Vanderbilt University, Nashville, TN, USA
    Severe pertussis in infants
  • 14.00-14.30 Fritz Wirsing Von Konig, Medizin Krefeld MVZ GmbH, Krefeld, Germany
    Biological diagnosis of Bordetella infections
  • 14.30-14.45 Joshua Eby, University of Virginia, VA, USA
    Short talk: Modulation of Neutrophil Death by the Bordetella Adenylate Cyclase Toxin and Cyclic AMP
  • 14.45-15.00 Rajendar Deora, Wake Forest school of Medicine, Winston-Salem, NC, USA
    Short talk: Utilization of genomic mining to identify a Bordetella pertussis locus involved in Cellular Adherence, Resistance to Antimicrobial Peptides and PMN-mediated Killing
  • 15.00-15.30 Tea/ Coffee

Session -4 New models and approaches to vaccination(Chair: Drusilla Burns)

  • 15.30-16.00 Kingston Mills, Trinity College Dublin, Ireland
    Rational design of a new pertussis vaccine based on adjuvants that induce
    protective cellular immunity
  • 16.00-16.30 Tod Merkel, DBPAP/CBER/FDA, Bethesda, USA
    Evaluating the host response to infection and vaccination in the baboon model of pertussis
  • 16.30-17.00 Camile Locht, Institut Pasteur de Lille, France
    Maternal versus neonatal immunization against pertussis, or both
  • 17.00 -17.15 Arno van der Ark, Intravacc, Bilthoven, The Netherlands
    Short talk: Molecular Engineering of a Pertussis Outer Membrane Vesicle Vaccine
  • 17.15 -17.30 Maria Eugenia Rodriguez, Universidad Nacional de La Plata, Argentina
    Short talk: Two Antigens Identified by Immunoproteomics Proved to Be Good Candidates for a New Generation of Pertussis Acellular Vaccines
  • 19.30 Banquet

Wednesday 11th September

Session-5 The way forward: Strategies to address problems with pertussis vaccine (Chair: Stanley Plotkin)

  • 8.45 – 10.15 What can be done to improve pertussis vaccines?
    Participants to include: Frits Mooi (new strains); Eric Harvill (new components); Nathalie Garcon (new adjuvants) and Camille Locht (live vaccines).
  • 10.15-10.45 Coffee
  • 10.45- 12.15 Round table discussion
    Participants to include: Stanley Plotkin (Chair) Linda Hanssens, Michael Decker, Rino Rappuoli, Jan Poolman, Peter McIntyre, John Robbins and Drusilla Burns.
    12.15-12.30 Xin-Xing Gu, NIAID/NIH, Bethesda, MD, USA
    Short talk: NIAID/NIH funding mechanisms and resources for pertussis research and product development
  • 12.30 Close of meeting